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Endocrine Abstracts

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ea0084op-11-54 | Oral Session 11: Young Investigators / Basic | ETA2022

Study of target tissue-resident immune cells in graves’ disease and orbitopathy (star-GO): preliminary findings with a novel extensive immunophenotyping panel

Maioli Sara , Salvi Mario , Moschetti Giorgia , Crosti Mariacristina , Crivicich Erica , Di Marco Francesco , Curro Nicola , Dolci Alessia , Arosio Maura , Mantovani Giovanna , Dayan Colin , Geginat Jens , Muller Ilaria

Background and Aims: Graves’ disease (GD) and orbitopathy (GO) are characterised by the presence of pathological anti-thyrotropin receptor antibodies. In thyroid autoimmunity, especially GD and GO, a dysregulation of several T cell subpopulations has been proposed, especially T regulatory (Treg) and T helper 17 (Th17) cells, determining (auto)immunity inhibition and enhancement, respectively. T follicular cells (Tf) within germinal centres (GC: aggregates of lymphocytes w...
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ea0092ps1-10-09 | Basic Thyroid Gland, Iodine & Autoimmunity Basic | ETA2023

Analysis of T- and B- lymphocytic infiltrate of target tissues in patients with graves’ disease and orbitopathy

Maioli Sara , Salvi Mario , Moschetti Giorgia , Crosti Mariacristina , Crivicich Erica , Di Marco Francesco , Rossi Giada , Curro Nicola , Dolci Alessia , Arosio Maura , Mantovani Giovanna , Dayan Colin , Geginat Jens , Muller Ilaria

Objectives: In Graves’ disease (GD) and Graves’ orbitopathy (GO) self-reactive lymphocytes escape immune tolerance, although the underlying mechanisms are not fully understood. We aimed to characterize the immune signatures of target tissue-resident lymphocytes in relation to GD and GO.Methods: Lymphocytes were derived from blood and ultrasound-guided-fine-needle aspiration (US-FNA) of thyroid and neck lymph nodes (LNs) of the following patient...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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